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Kiledjian Lab - Publications

Jiao, X., Doamekpor, S., Bird, J.G., Nickels, B.E., Tong, L., Hart, R.P. and Kiledjian, M. 5´-end NAD+ cap in human cells promotes RNA decay through DXO-mediated deNADding. Cell, 2017 (in press).

Mauer, J., Luo, X., Blanjoie, A., Jiao, X., Grozhik, A.V., Patil, D.P., Linder, B., Pickering, B.F., Vasseur, J-J., Chen, Q., Gross, S.S., Elemento, O., Debart, F., Kiledjian, M. and Jaffrey, S.R. Reversible methylation of m6Am in the 5´ cap controls mRNA stability. Nature, 2017, 541:371-375. epub 12/21/16. [abstract] [pdf]

Grudzien-Nogalska, E. and Kiledjian, M. New Insights into Decapping Enzymes and Selective mRNA Decay. WIREs RNA, 2017, Volume 8. epub 7/17/16. [abstract] [pdf]

Popovitchenko, T., Thompson, K., Viljetic, B., Jiao, X., Kontonyiannis, D.L., Kiledjian, M., Hart, R.P. and Rasin, M.R. The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex. Science Reports, 2016, Jul 7;6:28998. doi: 10.1038/srep28998. [abstract] [pdf]

Castellanos-Rubio, A., Fernandez-Jimenez, N., Kratchmarov, R., Luo, X., Bhagat, G., Green, P., Schneider, R., Kiledjian, M., Bilbao, R., and Ghosh, S.  A long non-coding RNA that is associated with susceptibility to celiac disease.  Science, 352:91-95. (Highlighted in Huarte M.,  Science, 2016, 352:43-44). [abstract] [pdf]

Grudzien-Nogalska E, Jiao X, Song MG, Hart RP, Kiledjian M. Nudt3 is an mRNA decapping enzyme that modulates cell migration. RNA, 2016, 22: 773-781. [abstract] [pdf]

Wang, V.Y.F., Jiao, X., Kiledjian, M. and Tong, L. Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.  Nuc. Acids Res., 2015, 43:6596-6606. [abstract] [pdf]

Kraushar, M., Viljetic, B., Wijeratne, H.R.S., Thompson, K., Jiao, X., Pike, J., Medvedeva, V., Groszer, M., Kiledjian, M., Hart, R. and Rasin, M.R. Thalamic WNT3 secretion spatiotemporally regulates the neocortical ribosome signature and mRNA translation to specify neocortical cell subtypes. J Neurosci., 2015, 35:10911-101092. [abstract] [pdf]

Zhou, M., Bail, S., Plasterer, H.L., Rusche, J., Kiledjian, M. DcpS is a transcript-specific modulator of RNA in mammalian cells. RNA, 2015, 21:1306-1312. [abstract] [pdf]

Kiledjian, M. Twenty years of RNA and mRNA decay. RNA, 2015, 21(4): p. 664-666. [pdf]

Ahmed, I., Buchert, R., Zhou, M., Jiao, X., Mittal, K., Sheikh, T., Scheller, U., Vasli, N., Rafiq, M.A., Brohi, M.Q., Mikhailov, A., Ayaz, M., Bhatti, A., Sticht, H., Nasr, T., Carter, M., Uebe, S., Reis, R., Ayub, M., John, P., Kiledjian, M., Vincent, J.B., Jamra, R.A. Mutations in DCPS and EDC3 in Autosomal Recessive Intellectual Disability Indicate a Crucial Role for mRNA Decapping in Neurodevelopment. Hum. Mol. Genet., 2015, 24:3172-80. [abstract] [pdf]

Tan, D., Zhou, M.,  Kiledjian, M., and Tong, L.  The ROQ domain of Roquin recognizes mRNA constitutive decay element and double-stranded RNA.  Nat. Struc. Mol. Biol., 2014, 8:679-85. [abstract] [pdf]

Jurado, A.R., Tan, D., Jiao, X., Kiledjian, M. and Tong, L. Structure and function of pre-mRNA 5’-end capping quality control and 3’-end processing.  Biochemistry,2014, 53: 1882-1898. [abstract]

Gogliotti, R.G., Cardona, H., Singh, J., Bail, S., Emery, C., Kuntz, N., Jorgensen, M., Durens, M., Xia, B., Barlow, C., Heier, C., Plasterer, H.L., Jaques, V., Kiledjian, M., Jarecki, J., Rusche, J. and DiDonato, C.J.  The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models.  Hum. Mol. Genet., 2013, 22:4084-4101. [abstract]

Jiao, X.,  Chang, J.H., Chiba, K., Kilic, T.,  Tong, L. and Kiledjian, M. A mammalian pre-mRNA 5´-end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.  Mol. Cell, 2013, 50:104-115. [abstract]

Song, M., Bail, S. and Kiledjian, M.  Multiple Nudix Family Proteins Possess mRNA Decapping Activity.  RNA, 2013, 19;390-399. [abstract]

Awe, J.P., A. Vega Crespo, Y. Li, M. Kiledjian and J.A. Byrne.  BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells. Stem Cell Res Ther, 2013, 4: 15.  [Epub ahead of print]. [abstract]

Chang JH, Jiao X, Chiba K, Oh C, Martin CE, Kiledjian M, Tong L. Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Nat Struct Mol Biol, 2012, 19:1011-1017. [abstract]

Sinturel F, Bréchemier-Baey D, Kiledjian M, Condon C, Bénard L. Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast. Proc Natl Acad Sci USA, 2012, 109:8264-8269. [abstract]

Li Y, Dai J, Song M, Fitzgerald-Bocarsly P, Kiledjian M. Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7.  Mol Cell Biol, 2012, 32:1164-1172. [abstract] [pdf]

Li, Y., Song, M. and Kiledjian, M. Differential Utilization of Decapping Enzymes in Mammalian mRNA Decay Pathways.  RNA, 2011, 17:419-428. [abstract] [pdf]

Jiao, X.,  Xiang, S., Oh, C., Martin, C.E., Tong, L. and Kiledjian, M.    Identification of a quality control mechanism for mRNA 5' end capping.  Nature, 2010, 467:608-611. [abstract]

Song, M., Li, Y. and Kiledjian, M.    Multiple mRNA Decapping Enzymes in Mammalian Cells.  Mol. Cell, 2010,  40:423-432. [abstract]

Li, Y. and Kiledjian, M.    Regulation of mRNA Decapping.  WIREs RNA., 2010, 1:252-265. [abstract]

Bail, S., Swerdel, M., Liu, H., Jiao, X., Hart, R.P. and Kiledjian, M. Differential regulation of microRNA Stability.  RNA,  2010, 5:1032-9. [abstract]

Jiao, X., Chen, H., Chen, J., Herrup, K., Firestein, B.L. and Kiledjian, M. Modulation of Neuritogenesis by a Protein Implicated in X-linked Mental Retardation. J Neurosci., 2009,  29:12419-12427.[abstract]

Li, Y., Ho, E.S., Gunderson, S.I. and Kiledjian, M. Mutational analysis of a Dcp2 binding element reveals general enhancement of decapping by 5′ end stem-loop structures.  Nucleic Acids Res., [abstract]

Xiang, S., Cooper-Morgan, A., Jiao, X.,Kiledjian, M., Manley, J.L., Tong, L.Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.   Nature, 2009  458:784-788. [abstract]

Bail, S. and Kiledjian, M. Tri- to be Mono- for Bacterial mRNA Decay.  Structure17:317-319. [abstract]

Singh, J., Salcius, M., Liu S.W., Staker, B.L., Mishra, R., Thurmond, J., Michaud, G., Mattoon, D.R., Printen, J., Christensen, J., Bjornsson, J.M., Pollok, B.A., Kiledjian, M., Stewart, L., Jarecki, J. and Gurney, M.E. DcpS as a Therapeutic Target for Spinal Muscular Atrophy. ACS Chemical Biology, 2008  3:711-722. [abstract]

Liu, S.W., Welch, S., Jiao, X. and Kiledjian, M.Analysis of Mammalian mRNA Decapping. Methods Enzymol. 2008  448:1-21. [abstract]

Bail, S. and Kiledjian, M.DcpS, a general modulator of cap-binding protein-dependent processes? RNA Biol. 2008  5:4, 216-219. [abstract]

Lin, M.D., Jiao, X., Grima, D., Newbury, S.F., Kiledjian, M. and Chou, T.B.Drosophila processing bodies in oogenesis. Dev Biol, 2008  322:276-288. [abstract]

Liu, S.W., Rajagopal, V., Patel, S.S. and Kiledjian, M.Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme. JBC, 2008 283:16427-16436. [abstract]

Shen, V., Liu, H., Liu, S.W., Jiao, X. and Kiledjian, M.DcpS scavenger decapping enzyme can modulate pre-mRNA splicing. RNA, 2008 14:1132-1142. [abstract]

Li, Y., Song, M.G. and Kiledjian, M. Transcript-Specific Decapping and Regulated Stability by the human Dcp2 Protein. Mol. Cell. Biol., 2008  28:939-948.  [abstract]

Song, M.G. and Kiledjian, M.Terminal Oligo U-tract Mediated Stimulation of Decapping. RNA, 2007 13:2356-2365. [abstract] [pdf]

Bail, S. and Kiledjian, M.P-Bodies. McGraw-Hill Yearbook of Science & Technology. McGraw Hill, New York. 2007 171-173.

Liu, H. and Kiledjian, M.An Erythroid-Enriched Endoribonuclease (ErEN) Involved in a-globin mRNA Turnover. Protein & Peptide Letters, 2007 14:131-136. [abstract]

Shen, V. and Kiledjian, M.A View to a Kill: Structure of the RNA Exosome. Cell, 2006 15:1093-1095. [abstract] [pdf]

Jiao, X., Wang, Z. and Kiledjian, M.Identification of an mRNA Decapping Regulator Implicated in X-linked Mental Retardation. Mol. Cell, 2006 24:713-722. [abstract] [pdf]

Liu, H. and Kiledjian, M.Decapping the message: a beginning or an end. Biochem Soc Trans., 2006 34:35-38. [abstract] [pdf]

Shen, V. and Kiledjian, M.Decapper comes into focus. Structure, 2006 14:171-172. [abstract] [pdf]

Bail, S. and Kiledjian, M.More than 1 + 2 in mRNA decapping. Nat Struct Mol Biol., 2006 13:7-9. [abstract] [pdf]

Carr-Schmid, A., Jiao, X. and Kiledjian, M.Identification of mRNA bound to RNA binding proteins by differential display. Methods Mol Biol., 2006 317:299-314. [abstract]

Liu, H. and Kiledjian, M.Scavenger decapping activity facilitates 5' to 3' mRNA decay. Mol Cell Biol., 2005 25:9764-9772. [abstract] [pdf]

Cohen, L.S., Mihkli, C., Jiao, X., Kiledjian, M., Kunkel, G. and Davis, R.E.Dcp2 Decaps m2,2,7GpppN�Capped RNAs and its Activity is Sequence and Context Dependent. Mol Cell Biol., 2005 25: 8779-8791. [abstract] [pdf]

Liu, S.W., Liu, H., Jiao, X., Gu, M., Lima, C.D., and Kiledjian, M.Functional analysis of mRNA scavenger decapping enzymes. RNA, 2004 10:1412-1422. [abstract] [pdf]

Khanna, R. and Kiledjian, M.Poly(A)-binding-protein-mediated regulation of hDcp2 decapping in vitro. EMBO J., 2004 23:1968-1976. [abstract] [pdf]

Gu, M., Fabrega, C., Liu, S.W., Liu, H., Kiledjian, M., and Lima, C.D.Insights into the structure, mechanism and regulation of the scavenger decapping activity. Mol. Cell, 2004 14:67-80. [abstract] [pdf]

Piccirillo, C., Khanna, R. and Kiledjian, M.Functional characterization of the mammalian mRNA decapping enzyme hDcp2. RNA, 2003 9:1138-1147. [abstract] [pdf]

Steiger, M., Carr-Schmid, A., Schwartz,, D.C., Kiledjian, M. and Parker, R.Analysis of recombinant yeast decapping enzyme. RNA, 2003 9:231-238. [abstract] [pdf]

Rodgers, N.D., Wang, Z., and Kiledjian, M.Regulated a-globin mRNA decay is a cytoplasmic event proceeding through 3'-to-5' exosome-dependent decapping. RNA, 2002 12:1526-1537. [abstract] [pdf]

Wang, Z., Jiao, X., Carr-Schmid, A.  and Kiledjian, M.The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc Natl Acad Sci U S A., 2002  99:12663-12668. [abstract] [pdf]

Liu, H., Rodgers, N., Jiao, X, and Kiledjian, M.The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. EMBO J., 2002 21:4699-4708. [abstract] [pdf]

Rodgers, N.D.., Jiao, X, and Kiledjian, M.Identifying mRNAs bound by RNA-binding proteins using affinity purification and differential display. Methods, 2002 26:115-122. [abstract] [pdf]

Jiao, X., Trifillis, P. and Kiledjian, M.Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein. Biol Reprod., 2002 66:475-485. [abstract] [pdf]

Rodgers, N., Wang, Z, and Kiledjian, M.Characterization and purification of a mammalian endoribonuclease specific for the alpha -globin mRNA. J Biol Chem., 2002 277:2597-2604. [abstract] [pdf]

Wang, Z, and Kiledjian, M.Functional link between the mammalian exosome and mRNA decapping. Cell, 2001 107:751-762. [abstract] [pdf]

Wang, Z. and Kiledjian, M.The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity. Mol Cell Biol., 2000 20:6334-6341. [abstract] [pdf]

Wang, Z. and Kiledjian, M.Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage. EMBO J., 2000 22:295-305. [abstract] [pdf]

Barnhart, B., .Kosinski, P., Wang, Z., Ford, G.S., Kiledjian, M. and Covey, L.R.Identification of a Complex that binds to the CD154 3-UTR: Implications for a Role in Message Stability during T cell Activation. J. Immunology, 2000 165:4478-4486 [abstract] [pdf]

Trifillis, P., Day, N. and Kiledjian, M.Finding the right RNA: identification of cellular mRNA substrates for RNA-binding proteins. RNA, 1999 5:1071-1082 [abstract] [pdf]

Wang, Z, Day, N., Trifillis, P. and Kiledjian, M.An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro. Mol Cell Biol., 1999 19:4552-4560 [abstract] [pdf]

Kiledjian, M., Day, N., and Trifillis, P.Purification and RNA-binding properties of the Polycytidylate-Binding Proteins aCP1 and aCP2. Methods, 1999 17:84-91 [abstract] [pdf]

Kiledjian, M., DeMaria, C.T., Brewer, G. and Novick, K.Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol Cell Biol, 1997 17:4870-4876 [abstract] [pdf]

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