NJ Autism Grant Awarded: Reelin protein and autism
NJ Autism Grant Awarded: Reelin protein and autism Prof. Gabriella D'Arcangelo was recently awarded a grant from the New Jersey Governor's Council for Medical Research and Treatment of Autism. The project seeks to investigate the Reelin signaling pathway in synapse formation in developing mouse brain. Autism is believed to be associated with altered synaptic function.
NJ Autism Grant Awarded: Cypin and Neuroligin-1 in synaptogenesis
NJ Autism Grant Awarded: Cypin and Neuroligin-1 in synaptogenesis Prof. Bonnie Firestein was recently awarded a grant from the New Jersey Governor's Council for Medical Research and Treatment of Autism. The project will determine how cypin and Neuroligin-1 (NLGN-1) regulate excitatory synapse formation, since creating the appropriate number and type of connections is essential for proper brain development and function. Defects in synapse formation underlie a number of cognitive disorders, including autism and autism spectrum disorders.
A new model of Alzheimer's Disease
A new model of Alzheimer's Disease Professor Karl Herrup recently published a novel hypothesis to explain the etiology of Alzheimer's Disease. Appearing in the December 15, 2010 issue of the Journal of Neuroscience, Prof. Herrup's hypothesis is that AD is triggered by three steps, starting with an initiating injury, continuing with an inflammatory response, and resulting in a change in cell state. This model places the so-called "amyloid theory" in context of a larger progression of events, helping to explain why therapies targeting amyloid may be insufficient to ameliorate symptoms. Read the profile of Dr. Herrup and his model in a recent Rutgers news release.
Epigenetic link to neurodegeneration in ataxia?
Epigenetic link to neurodegeneration in ataxia? Professor Karl Herrup recently reported in Nature Medicine that children born with ataxia telangiactasia, a disorder known to be related to DNA repair, can also be linked to proteins that change epigenetic regulation in neurons. Results demonstrated that inhibiting HDAC4 protein in a mouse model was able to reduce symptoms. Read the announcement of Prof. Herrup's discover in a recent Rutgers Today article.