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Epigenetic link to neurodegeneration in ataxia?

karlherrupEpigenetic link to neurodegeneration in ataxia? Professor Karl Herrup recently reported in Nature Medicine that children born with ataxia telangiactasia, a disorder known to be related to DNA repair, can also be linked to proteins that change epigenetic regulation in neurons. Results demonstrated that inhibiting HDAC4 protein in a mouse model was able to reduce symptoms. Read the announcement of Prof. Herrup's discover in a recent Rutgers Today article.

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