Epigenetic link to neurodegeneration in ataxia? Professor Karl Herrup recently reported in Nature Medicine that children born with ataxia telangiactasia, a disorder known to be related to DNA repair, can also be linked to proteins that change epigenetic regulation in neurons. Results demonstrated that inhibiting HDAC4 protein in a mouse model was able to reduce symptoms. Read the announcement of Prof. Herrup's discover in a recent Rutgers Today article.
Epigenetic link to neurodegeneration in ataxia?