A new model of Alzheimer's Disease Professor Karl Herrup recently published a novel hypothesis to explain the etiology of Alzheimer's Disease. Appearing in the December 15, 2010 issue of the Journal of Neuroscience, Prof. Herrup's hypothesis is that AD is triggered by three steps, starting with an initiating injury, continuing with an inflammatory response, and resulting in a change in cell state. This model places the so-called "amyloid theory" in context of a larger progression of events, helping to explain why therapies targeting amyloid may be insufficient to ameliorate symptoms. Read the profile of Dr. Herrup and his model in a recent Rutgers news release.
A new model of Alzheimer's Disease