• David Margolis
  • David Margolis
  • Associate Professor
  • Click for website
  • Phone: (848) 445-9533
  • Fax: (732) 445-1794
  • Office: B243 Nelson Labs
  • Click for Research Website
  • Biography:

    Sc.B., Brown University, Providence RI
    Ph.D., University of Washington, Seattle WA

    Postdoctoral training: Fritjof Helmchen, advisor. University of Zurich, Switzerland. 

    NARSAD Young Investigator
    Whitehall Foundation Fellow
    Associate Editor, Frontiers in Neural Circuits
    Editorial Board, Scientific Reports
    Graduate Faculty, Molecular Biosciences
    Graduate Faculty, Biomedical Engineering

  • Research Group: Neuroscience
  • Research Interests:

    In vivo imaging of neural circuit plasticity

  • News Articles:
  • Dr. David Margolis and His Team Discover New Role for Sensory Signals in the Brain
  • Current Research:


    Visualizing long-term circuit plasticity

    Changes in neural circuit activity play a critical role in many aspects of nervous system function throughout life, from development to learning and the progression of disease. We study how neural circuits of the mouse neocortex encode the sensory environment, and how the rules of encoding undergo plasticity during altered sensory experience. We use chronic in vivo imaging techniques to measure functional changes of both large-scale activity maps and the underlying local neuronal populations. Two-photon imaging of neurons expressing genetically encoded activity sensors allows us to repeatedly measure activity of the exact same neurons over days and weeks as plasticity takes place. Defining the logic of functional plasticity within cortical circuits has implications for understanding how the brain changes under pathological conditions and for identifying cellular targets to enhance functional recovery. 


    We are interested in:

    The roles of genetically and anatomically defined types of cortical neurons in sensory processing and plasticity. What are the relative contributions of excitatory and inhibitory neurons to the expression of plasticity? Do microcircuits of excitatory neurons undergo specific forms of plasticity depending on their axonal projection targets?

    Effects of learning on sensory and sensorimotor processing. Do learning and sensory deprivation impact ensemble activity by similar mechanisms? How is local and large-scale neural circuit activity modified over weeks during the transition from learning to memory to forgetting? We approach these questions by imaging brain activity as mice learn to perform simple behaviors.

    Alteration of neuronal circuit function by injury and disease. We investigate the effects of traumatic brain injury (TBI) on neural circuits and behavior.


  • PubMed Publications:

    For CBN's main publication search, click here.

  • Research Summary:

    In vivo imaging of neural circuit plasticity

  • Recruiting New Research Assistants: 2021-2022
  • Research Summary:

    Neural circuit function and plasticity in mice

  • How to Apply:


  • Semesters Accepting Students:

    Fall: Yes
    Spring: Yes
    Summer: Yes

  • Research Preferences:

    Interest in learning experimental and computational skills in a systems/circuits neuroscience lab