Peng Jiang Lab

Organoid chimeric brain

Research Directions:

The Jiang lab studies the cellular and molecular basis of human neural development and pathogenesis of neurological disorders by using human patient-derived induced pluripotent stem cells (a.k.a. iPSCs). We create iPSC-based in vitro cerebral organoid model and in vivo human-mouse chimeric brain model to investigate how aberrant gene expression in Down syndrome causes abnormal brain development and intellectual disability, and also how aberrant gene expression leads to accelerated aging and early-onset Alzheimer's disease in Down syndrome.

In addition, human iPSCs hold great promise for developing cell therapies to replace damaged brain cells and restore brain functions after CNS injury. We also study how to derive functionally competent neural cells from human iPSCs for neural repair. The basic and translational stem cell research we are pursuing critically bridges between the understanding of human neural development and degeneration in normal and diseased conditions, and the development of stem cell medicine to treat neurological disorders.

Support Our Research:

We greatly appreciate funding support from the NIH (NINDS, NIA, & NICHD) and donations from Alexander's Angels, Inc.

If you are interested in supporting our research, please:

Either use the online giving link ( that will take you directly to a giving form specifically for Dr. Jiang’s research

Or send a check by mail to:
Rutgers University Foundation
PO Box 193
New Brunswick, NJ 08903-0193
In the memo, it should indicate that the gift is in support of Dr. Peng Jiang’s research, allocation #22047. 

Contact Peng Jiang

Peng Jiang
Department of Cell Biology and Neuroscience
Rutgers University
Nelson Biology Labs
604 Allison Road, Room B209
Piscataway, NJ 08854-8082

(848) 445-3118 Lab