Organoid chimeric brain

Research Directions:

The Jiang lab studies the cellular and molecular basis of human neural development and pathogenesis of neurological disorders by using human patient-derived induced pluripotent stem cells (a.k.a. iPSCs). We create iPSC-based in vitro cerebral organoid model and in vivo human-mouse chimeric brain model to investigate mechanisms underlying neurodevelopmental disorders (e.g, Down syndrome, autism spectrum disorder), as well as age-related neurodegenerative diseases (e.g., Alzheimer's disease).

In addition, human iPSCs hold great promise for developing cell therapies to replace damaged brain cells and restore brain functions after CNS injury. We also study how to derive functionally competent neural cells, particularly macroglial and microglial cells, from human iPSCs for neural repair.

The basic and translational stem cell research we are pursuing critically bridges between the understanding of human neural development and degeneration in normal and diseased conditions, and the development of stem cell medicine to treat neurological disorders.

Support Our Research:

We greatly appreciate funding support from the NIH (NINDS, NIA, NICHD, & NIDA), NJDOH, and donations from Alexander's Angels, Inc.

If you are interested in supporting our research, please:

Either use the online giving link ( that will take you directly to a giving form specifically for Dr. Jiang’s research

Or send a check by mail to:
Rutgers University Foundation
PO Box 193
New Brunswick, NJ 08903-0193
In the memo, it should indicate that the gift is in support of Dr. Peng Jiang’s research, allocation #22047. 

Join Our Team:

We always look for motivated Postdoctoral Researchers. You are welcome to send CV and a cover letter describing your research interests to This email address is being protected from spambots. You need JavaScript enabled to view it.

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