Selected representative publications
Jin M, Ma Z, Zhang H, Dang R, Papetti AV, Stillitano AC, Zou L, Goldman SA, Jiang P. Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions. Cell Reports. 2026 Jan 6;45(1):116794. doi: 10.1016/j.celrep.2025.116794. Epub ahead of print. PMID: 41499239.
Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Yu H, Papetti AV, Liu Y, Finkbeiner S, Head E, Liu Y, Jiang P. A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease. Nature Neuroscience. 2025 Nov 24. doi: 10.1038/s41593-025-02117-8. Epub ahead of print. PMID: 41286452.
Qiao M, Jiang P. From sentinels to engineers: The future of microglia in brain regeneration. Cell Stem Cell. 2025 Oct 2;32(10):1487-1488. doi: 10.1016/j.stem.2025.09.004.
Papetti AV, Jin M, Ma Z, Stillitano AC, Jiang P. Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies. Neuron. 2025 Apr 22:S0896-6273(25)00256-9. doi: 10.1016/j.neuron.2025.03.036.
Jiang P, Jin M. Replacing microglia to treat Alzheimer’s disease. Cell Stem Cell. 2023;30(8):1001-3. doi: 10.1016/j.stem.2023.07.005.
Jin M, Alam MM, Liu AY, Jiang P. Rag2-/- accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies. Stem Cell Reports. 2022 Nov 8;17(11):2381-2391. doi: 10.1016/j.stemcr.2022.09.012.
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 2022;29(7):1135-53 e8. doi: 10.1016/j.stem.2022.06.007.
Xu R, Boreland AJ, Li X, Erickson C, Jin M, Atkins C, Pang ZP, Daniels BP, Jiang P. Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology. Stem Cell Reports, 2021 Aug 10; 16(8):1923-1937. DOI: 10.1016/j.stemcr.2021.06.011. PMID: 34297942
Jiang, P., Turkalj, L., Xu, R. High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells. Cell Stem Cell, 2020. May 7; 26, 629-631. DOI: 10.1016/j.stem.2020.04.004
Xu R, Li X, Boreland AJ, Posyton A, Kwan K, Hart RP, Jiang P. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nature Communications. 2020 Mar 27;11(1):1577. DOI: 10.1038/s41467-020-15411-9.
Kim, H., Xu, R., Padmashri, R., Dunaevsky, A., Liu, Y., Dreyfus, C. F., & Jiang, P. Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins. Stem Cell Reports, 2019 May 12, 890-905. PMID: 31091434. DOI: 10.1016/j.stemcr.2019.04.011
Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., Pang, Z. P., Kim, W. Y., Hart, R. P., Liu, Y., Jiang, P. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. DOI: 10.1016/j.stem.2019.04.014.
Chen C, Chan A, Wen H, Chung SH, Deng W, Jiang P. Stem and progenitor cell-derived astroglia therapies for neurological diseases. Trends in Molecular Medicine. 2015 Nov;21(11):715-29. doi: 10.1016/j.molmed.2015.09.003.