The goal of our research is to create human pluripotent stem cell (PSC) neural differentiation models for studying human neural development pathways and corresponding pathogenesis of neurodevelopmental diseases, and for developing stem cell regenerative medicine to treat neurological disorders. We have been using a combination of multidisciplinary techniques in our research, stem cell reprogramming, electrophysiology/patch-clamp recording, imaging techniques, molecular/cell biology (including CRISPR/cas9 technology), biochemistry, pharmacology, microarray and RNA-sequencing techniques, transgenic and surgically induced animal models, and animal behavioral testing.
