Selected representative publications
Review Articles
1. Papetti AV, Jin M, Ma Z, Stillitano AC, Jiang P. Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies. Neuron. 2025;113:2230–2250. DOI: 10.1016/j.neuron.2025.03.036.
2. Chen C, Chan A, Wen H, Chung SH, Deng W, Jiang P. Stem and progenitor cell-derived astroglia therapies for neurological diseases. Trends in Molecular Medicine. 2015;21(11):715–729. DOI: 10.1016/j.molmed.2015.09.003.
Commentaries/Perspectives
1. Qiao M, Jiang P. From sentinels to engineers: The future of microglia in brain regeneration. Cell Stem Cell. 2025;32(10):1487–1488. DOI: 10.1016/j.stem.2025.09.004.
2. Jiang P, Jin M. Replacing microglia to treat Alzheimer’s disease. Cell Stem Cell. 2023;30(8):1001–1003. DOI: 10.1016/j.stem.2023.07.005.
3. Jiang P, Turkalj L, Xu R. High-fidelity modeling of human microglia with pluripotent stem cells. Cell Stem Cell. 2020;26(5):629–631. DOI: 10.1016/j.stem.2020.04.004.
Original Research Articles
1. Jin M, Ma Z, Zhang H, Dang R, Papetti AV, Stillitano AC, Zou L, Goldman SA, Jiang P. Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions. Cell Reports. 2026;45(1):116794. DOI: 10.1016/j.celrep.2025.116794.
2. Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Yu H, Papetti AV, Liu Y, Finkbeiner S, Head E, Liu Y, Jiang P. A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease. Nature Neuroscience. 2026;29(1):25–39. DOI: 10.1038/s41593-025-02117-8.
3. Jin M, Alam MM, Liu AYC, Jiang P. Rag2−/− accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies. Stem Cell Reports. 2022;17(11):2381–2391. DOI: 10.1016/j.stemcr.2022.09.012.
4. Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 2022;29(7):1135–1153.e8. DOI: 10.1016/j.stem.2022.06.007.
5. Xu R, Boreland AJ, Li X, Erickson C, Jin M, Atkins C, Pang ZP, Daniels BP, Jiang P. Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology. Stem Cell Reports. 2021;16(8):1923–1937. DOI: 10.1016/j.stemcr.2021.06.011.
6. Xu R, Li X, Boreland AJ, Posyton A, Kwan K, Hart RP, Jiang P. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nature Communications. 2020;11(1):1577. DOI: 10.1038/s41467-020-15411-9.
7. Kim H, Xu R, Padmashri R, Dunaevsky A, Liu Y, Dreyfus CF, Jiang P. Pluripotent stem cell-derived cerebral organoids reveal human oligodendrogenesis with dorsal and ventral origins. Stem Cell Reports. 2019;12(5):890–905. DOI: 10.1016/j.stemcr.2019.04.011.
8. Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, Jiang P. OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of Down syndrome. Cell Stem Cell. 2019;24(6):908–926.e8. DOI: 10.1016/j.stem.2019.04.014.