Undergraduate Course Descriptions

• Course Code: 01:146:447
• Semester(s) Offered: Fall, Spring
• Credits: 3
• CBN Core Courses: CBN Upper Level Courses
• Suggested Year: 4th
• Fall & Spring Synopsis

Prerequisites: Fundamentals of Neurobiology (01:146:245) and Fundamentals of Cell Biology (01:146:270).  Seniors only.

COURSE TITLE: CLINICAL NEUROBIOLOGY

COURSE CATALOG CODE AND SECTION NUMBER: 01:146:447 SEMESTER: FALL

COURSE INSTRUCTOR AND CONTACT INFORMATION

Course Director: Martin Grumet, PhD This email address is being protected from spambots. You need JavaScript enabled to view it. Course Faculty:  David Margolis, PhD This email address is being protected from spambots. You need JavaScript enabled to view it.

COURSE MEETING DAYS, TIMES, LOCATION, MODALITY

This course will be taught in person on Tues. & Thurs. 2:00 –3:20 PM; Tillet 226, Livingston Campus.

OFFICE HOURS / STUDENT SUPPORT HOURS

Student support hours are scheduled for Thursdays from 4:00 PM – 5:00 PM. Questions about lectures and course materials will be discussed in these sessions, which will take place in Nelson D251 Keck Conference room on Busch Campus. Students with personal issues are encouraged to make an appointment to meet with Professors; walk- ins are encouraged and will be accommodated whenever possible. Students who are concerned about a specific exam should write or make an appointment to the Professor no later than 1 week after the exam.

COURSE DESCRIPTION

This course focuses on development and function of the central nervous system with an emphasis on diseases and disorders. It has 4 modules: 1) CNS Development, Stem cells and Disease; 2) Neurological Disorders and Stem cells; 3) Neurodegenerative Diseases; and 4). Retinal function and degeneration, and Phantom limb pain.

Classes will focus on:

• Development of the nervous systems and the role of stem
• CNS disorders and diseases including demyelination, Amyotrophic Lateral Sclerosis, Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, and cancer.
• Zika and COVID19 Viral
• Spinal cord injury and neurotrauma, and treatments with cells and
• Retinal degeneration and Phantom limb pain

This course typically has ~80-110 students. Lectures will include breaks to allow for questions. Class participation is highly encouraged but will not be part of the final grade. The course is divided into four modules. The first three will be taught by Dr. Martin Grumet and the fourth by Dr. David Margolis. The weights of the exams are based on the numbers of lectures in each module and there are more lectures in the first and last module. The first exam will include 7 lectures and is worth 28% of your grade, the second and third exams will each have 5 lectures worth 20%, and the final has 8 lectures and is worth 32% of your grade.

REQUIRED TEXTS AND COURSE MATERIALS

There is no text for the course. Lecture notes will be posted on Canvas before class. These slides are considered homework and should be reviewed by students before class. Suggested texts for background are Essential Cell Biology 6th Edition by Bruce Alberts, ISBN 9781324033394, and Neuroscience 6th Edition by Dale Purves, ISBN-13: 978-1605353807 (chapters 1, 22 and 26). These texts have been used for Fundamentals of Cell and Developmental Biology, and Fundamentals of Neuroscience, respectively, and they serve as reference and foundational information for this course. You are expected to be familiar with the materials covered in these courses. All course materials are copyrighted by the University and the individual instructors. Unauthorized distribution of these materials could violate the University Academic Integrity Policy and may subject you to disciplinary action.

Exams: There will be four exams with a review session before each one. You should bring one computer or other electronic device only for the purpose of taking the exam on Canvas with Lockdown browser. Phones or other electronic devices are not allowed during exams: your phones should be placed on a desk in front of the class. You will not have access to course slides, or your own lecture notes during the exam. There will be ~35 questions on each exam. Exams will consist mostly of multiple-choice questions with several T/F. The first exam will be worth 28% of your grade, the second and third exams will each be worth 20%, and the final 32%, which is based on the number of lectures in each module 7, 5, 5, and 8, respectively. Exams may include diagrams.

Class time is devoted for review before each exam. Please communicate with Professors about expected absences (e.g. medical school interviews) as soon as possible prior to the exam. Absences on exam days that are not excused satisfactorily prior to the exam may lose up to ten points on a make-up exam and non-emergency excused absences may lose the opportunity to take a makeup.

Lockdown browser: Instructions for using Lockdown browser is at in an announcement one week prior to the first class. It is your responsibility to get this browser working on your laptop. We will run one or more tests to ensure the browser works for you. Please contact the Professor ASAP if the browser does not work for you.

Quizzes: There will be five quizzes for which you need to use Lockdown browser. The first will be on 9/1/26 the first day of class and will be worth 1 point for extra credit. In addition, there will be one quiz for each of the four modules. The subject of the quizzes will be the lecture given that day. Each of the four module quizzes will consist of 3 questions, 2 for credit that will be added to you score on each module exam (98 points maximum +2 points maximum from quiz; 98+2=100). The other question for extra credit will be added to your exam score in the same module. Quizzes can only be taken in class and there are no makeups or excuses for any reason.

Instructions for Exams

1. Bring a fully charged functioning laptop or ipad and bring your charger just in case. You can use only one electronic device. No smart phones. All phones will be place in front of the class during the
2. You will only access the Canvas exam, which will require a code ONLY provided in the classroom or under supervision of an approved proctor. There are no remote exams.
3. We will provide blank papers for scribbling during the exam, so bring your pens/pencils but no papers of your
4. Access to class notes and outside websites during the exam is not permitted. If for any reason your computer exits the exam, report every incident immediately to the Professor. Questions that are answered during these lapses (gaps) in your exam log may receive no credit if they are not reported to the Professor during the

TECHNICAL / TECHNOLOGY REQUIREMENTS

Students are invited to visit Rutgers Student Tech Guide website for resources: https://it.rutgers.edu/technology-guide/students/#new-brunswick

If you do not have the appropriate technology for financial reasons, please email the Dean of Students at This email address is being protected from spambots. You need JavaScript enabled to view it. for assistance. If you are facing other financial hardships, please visit the Office of Financial Aid: https://financialaid.rutgers.edu/.

LEARNING GOALS

Course and Department Learning Goals

The learning goals for this course are consistent with general goals set by the Department of Cell Biology and Neuroscience, as well as the Division of Life Sciences. They include:

• Master factual and conceptual knowledge in neurodevelopment, neurotrauma, nervous system disorders and cell transplantation that will provide a solid foundation for success in advanced training and professional
• Develop an ability to summarize, integrate and organize complex
• Develop an ability to use scientific reasoning to evaluate the potential for current research and new discoveries to improve your understanding of how to treat nervous system functions and disorders and its relevance to human health and to our

GRADING SCALE

A 90.00-100%

B+ 85.00-89.99%

B  80.00-84.99%

C+ 75.00-79.99%

C     67.00-74.99%

D 60.00-66.99%

F <60.00%

The cutoffs for the grades may be lowered if the final average for the class is below 85. Warning grades will be issued if a student has a failing grade after the first exam.

ASSESSMENT / GRADING COMPONENTS

The course is divided into 4 modules and there will be four 80-minute exams. The first three exams will be given in class on the date scheduled for the course, and the fourth a the date that needs to be determined. Exams will consist mostly of multiple-choice questions and several T/F. There will usually be ~35 questions on exams. The first exam will be worth 28% of your grade, the second and third grades will each be worth 20%, and the final 32%. In preparation for exams, students should study the slides, which serve as the lecture notes. The exams may include diagrams. Class time is devoted to review before each exam in the last lecture before the exam.

POLICIES

Attendance and Participation

Attendance is expected and encouraged for all classes. Students who don’t attend lectures may experience difficulties in hearing recordings and especially student questions during discussions in class. Students who do not attend class may miss some information that could compromise their exam scores. Students are expected to take exams on time, failure to do so could result in deductions of points. For best success in the course, we urge regular attendance in class.

If you anticipate not being able to take an exam, you must report absences in advance using the University self-reporting absence system: https://sims.rutgers.edu/ssra/ and notify the course director Dr. Martin Grumet in writing. When you self-report an absence, an email is automatically sent to the course director. You may be able to take a make-up exam with a documented absence indicating the reason for your absence. If you fail to contact Dr. Grumet by email of a missed exam within 2 days after the exam date you may be denied the opportunity to take a makeup and/or may lose points off your grade. Medical or other emergencies may be valid exceptions. If you anticipate missing an exam because of an interview or other important matter, you must write to Dr. Grumet in advance of the exam.

You should be familiar with Rutgers policy on attendance and cancellation of classes: https://sasundergrad.rutgers.edu/degree-requirements/policies/attendance-and- cancellation-of-classes. Students who have a prolonged health and/or financial issues that are impacting their academics and well-being over an extended period of time should contact the Dean of Students at This email address is being protected from spambots. You need JavaScript enabled to view it.. The Dean of Students may provide the instructor with a letter requesting flexibility.

Disability and Other Accommodations

Students in need of disability accommodations should register for accommodations and consult the policies and procedures of the Office of Disability Services website: https://ods.rutgers.edu

To receive consideration for reasonable accommodations, a student with a disability must contact the appropriate disability services office at the campus in a timely manner where you will be officially enrolled, participate in an intake interview, and provide documentation. Make sure that Professor Grumet is aware of your accommodation.

For other accommodations please consult:

• Academic Calendar: https://scheduling.rutgers.edu/scheduling/academic- calendar
• Rosters (with Absence and Warning information): https://sims.rutgers.edu/rosters
• Final Exam Scheduling: https://scheduling.rutgers.edu/scheduling/exam- scheduling
• Interfaith Calendar: https://interfaith-calendar.org

ACADEMIC INTEGRITY POLICY

You should be familiar with the University website on Academic Integrity: http://nbacademicintegrity.rutgers.edu/

In taking this course you agree to sign:

On my honor, I have neither received nor given any unauthorized assistance on any examination or assignment.

Rutgers University takes academic dishonesty very seriously. By enrolling in this course, you assume responsibility for familiarizing yourself with the Academic Integrity Policy and the possible penalties (including suspension and expulsion) for violating the policy. As per the policy, all suspected violations will be reported to the Office of Student Conduct. Academic dishonesty includes (but is not limited to):

• Cheating
• Plagiarism
• Aiding others in committing a violation or allowing others to use your work
• Failure to cite sources correctly
• Fabrication
• Using another person’s ideas or words without attribution, including re-using a previous assignment unauthorized collaboration
• Sabotaging another student’s work

If you are ever in doubt, consult your instructor.

STUDENT SUPPORT AND MENTAL WELLNESS

• Student Success Essentials: https://success.rutgers.edu
• Student Support Services: https://www.rutgers.edu/academics/student-support
• The Learning Centers: https://rlc.rutgers.edu/
• Rutgers Libraries: https://www.libraries.rutgers.edu/
• Bias Incident Reporting: https://studentaffairs.rutgers.edu/bias-incident-reporting
• Dean of Students – Student Support Office: https://success.rutgers.edu/resource/dean-students-student-support-office
• Office of Veteran and Military Programs and Services: https://veterans.rutgers.edu
• Student Health Services: http://health.rutgers.edu/
• Counseling, Alcohol and Other Drug Assistance Program & Psychiatric Services (CAPS): http://health.rutgers.edu/medical-counseling-services/counseling/
• Office for Violence Prevention and Victim Assistance: vpva.rutgers.edu/
• Office of Disability Services: https://ods.rutgers.edu/
• Basic Needs Assistance (food, housing, and other essentials): https://ruoffcampus.rutgers.edu/basic-needs
• Rutgers Student Food Pantry: https://ruoffcampus.rutgers.edu/food-pantry
• UWill: http://health.rutgers.edu/uwill/
• Rutgers Student Food Pantry: https://ruoffcampus.rutgers.edu/food-pantry

LockDown Browser Requirement

This course requires the use of LockDown Browser for online exams. Watch this video to get a basic understanding of LockDown Browser:

https://www.respondus.com/products/lockdown-browser/student-movie.shtml

A LockDown Exam in Canvas uses Respondus LockDown Browser to prevent students from accessing other apps, websites, or files during a test.

LockDown Browser locks the screen into Canvas and Blocks:

• Copy/paste
• Opening other tabs/apps
• Screen capture & printing

Download and install LockDown Browser on your computer from this link:

https://download.respondus.com/lockdown/download.php?id=762943427

Once Installed

• Quit all browsers (Safar, Chrome …)
• Open LockDown Browser from Applications folder
• Log into Canvas
• Navigate to the exam

Note: You won't be able to access an exam that requires LockDown Browser with a standard web browser. If this is tried, an error message will indicate that the test requires the use of LockDown Browser. Simply start LockDown Browser and navigate back to the exam to continue.

Getting Help

Several resources are available if you encounter problems with LockDown Browser:

• The Windows and Mac versions of LockDown Browser have a "Help Center" button located on the toolbar. Use the "System & Network Check" to troubleshoot If an exam requires you to use a webcam, also run the "Webcam Check" from this area
• Respondus has a Knowledge Base available from support.respondus.com. Select "LockDown Browser as the product to view helpful
• If you're still unable to resolve a technical issue with LockDown Browser, go to respondus.com and select "Submit a Ticket". Provide detailed information about your problem and what steps you took to resolve it.
• Alternatively, if you need help contact OIT at 833-646-4357.

• Course Code: 01:146:456
• Semester(s) Offered: Fall, Spring
• Credits: 3
• Suggested Year: 3rd/4th
• Spring Synopsis

Preparation for advanced graduate study in physiology and for medical physiology (first year medical school).  Focus on mammalian physiology and the whole animal (whole organ) approach. It can be used to satisfy the elective requirement of the CBN major. Prerequisite: System Physiology (01:146:356).

• Course Code: 01:146:465
• Semester(s) Offered: Fall, Spring
• Credits: 3
• CBN Core Courses: CBN Upper Level Courses
• Suggested Year: 3rd/4th
• Fall & Spring Synopsis

This course is offered Spring semester, and is intended primarily for students majoring in Cell Biology & Neuroscience. It counts as an Advanced course towards the CBN major (R10) or a Life Science Elective (R11). Other students with background knowledge in neuroscience can also register for this course.

The opioid epidemic highlights how chronic pain may result in addiction to painkillers. Understanding the fundamental underpinnings of the debilitating sensations of pain and addictive behaviors provides potential therapeutic avenues for treatment and intervention. The course will focus on the molecular, cellular, and neuroanatomical correlates of pain and addiction. The course consists of three modules. The first module will delve into how different ion channels sense temperature, mechanical stimulus, or pain. The second module will cover the neural circuitries that convey, integrate, and combine these percepts. Finally, students will learn the neuroanatomy and circuits that participate in addictive behavior.  Students must have a strong background in cell biology or neurobiology. Prerequisites: Fundamentals of Neurobiology (01:146:245) or Essentials of CBN (01:146:295).

• Course Code: 01:146:471
• Semester(s) Offered: Spring
• Credits: 3
• Spring Synopsis

Advanced laboratory methods in cell biology. Emphasis on microscopy, immunochemical techniques, bacterial and mammalian cell culture, and methods of identifying and separating macromolecules. It can be used to satisfy the laboratory requirement of the CBN major. Prerequisites: Fundamentals of Cell Biology (01:146:270), or permission of the instructor.